ParkinsonCanadaV1, France, Analysis, bibRecord, 000239

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Identifieur interne : 000239 ( France/Analysis ); précédent : 000238; suivant : 000240

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Auteurs : M. Berk [Australie] ; S. Dodd [Australie] ; M. Kauer-Sant'Anna [Canada] ; G. S. Malhi [Australie] ; M. Bourin [France] ; F. Kapczinski [Brésil] ; T. Norman [Australie]

Source :

Acta psychiatrica scandinavica. Supplementum [ 0065-1591 ] ; 2007.

RBID : Pascal:08-0007460

Descripteurs français

Pascal (Inist)
- Dopamine, Trouble bipolaire, Manie, Etat dépressif, Physiopathologie, Transmission dopaminergique, Psychopharmacologie, Article synthèse, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bipolar disorder, Depression, Dopamine, Dopaminergic transmission, Human, Mania, Pathophysiology, Psychopharmacology, Review.

Abstract

Objective: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. Method: A literature search was conducted using standard search engines Embase, PyschLIT, PubMed and MEDLINE. In addition, papers and book chapters known to the authors were retrieved and examined for further relevant articles. Results: Collectively, in excess of 100 articles were reviewed from which approximately 75% were relevant to the focus of this paper. Conclusion: Pharmacological models suggest a role of increased dopaminergic drive in mania and the converse in depression. In Parkinson's disease, administration of high-dose dopamine precursors can produce a 'maniform' picture, which switches into a depressive analogue on withdrawal. It is possible that in bipolar disorder there is a cyclical process, where increased dopaminergic transmission in mania leads to a secondary down regulation of dopaminergic receptor sensitivity over time. This may lead to a period of decreased dopaminergic transmission, corresponding with the depressive phase, and the repetition of the cycle. This model, if verified, may have implications for rational drug development.

Affiliations:

Links to Exploration step

Pascal:08-0007460

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. Method: A literature search was conducted using standard search engines Embase, PyschLIT, PubMed and MEDLINE. In addition, papers and book chapters known to the authors were retrieved and examined for further relevant articles. Results: Collectively, in excess of 100 articles were reviewed from which approximately 75% were relevant to the focus of this paper. Conclusion: Pharmacological models suggest a role of increased dopaminergic drive in mania and the converse in depression. In Parkinson's disease, administration of high-dose dopamine precursors can produce a 'maniform' picture, which switches into a depressive analogue on withdrawal. It is possible that in bipolar disorder there is a cyclical process, where increased dopaminergic transmission in mania leads to a secondary down regulation of dopaminergic receptor sensitivity over time. This may lead to a period of decreased dopaminergic transmission, corresponding with the depressive phase, and the repetition of the cycle. This model, if verified, may have implications for rational drug development.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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